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|
Characteristics
|
No. of participants
|
HR (95%CI)
|
P-value
|
P for interaction
|
|---|
|
Age (year)
| | | |
< 0.0001
|
|
< 40
|
106,447
|
4.53 (3.76–5.45)
|
< 0.0001
| |
|
> =40, < 60
|
71,176
|
3.54 (3.19–3.93)
|
< 0.0001
| |
|
> =60
|
23,675
|
2.67 (2.37–3.00)
|
< 0.0001
| |
|
Sex
| | | |
0.0150
|
|
Male
|
109,236
|
3.16 (2.90–3.45)
|
< 0.0001
| |
|
Female
|
92,062
|
3.84 (3.37–4.37)
|
< 0.0001
| |
|
BMI (kg/m2)
| | | |
0.0075
|
|
< 18.5
|
11,593
|
3.64 (1.53–8.64)
|
0.0034
| |
|
> =18.5, < 24
|
112,241
|
4.13 (3.62–4.71)
|
< 0.0001
| |
|
> =24, < 28
|
60,886
|
3.22 (2.90–3.58)
|
< 0.0001
| |
|
> =28, < 32
|
14,388
|
3.11 (2.64, 3.68)
|
< 0.0001
| |
|
> =32
|
2190
|
3.36 (2.33, 4.85)
|
< 0.0001
| |
|
SBP (mmHg)
| | | |
< 0.0001
|
|
< 140
|
181,383
|
3.48 (3.19–3.79)
|
< 0.0001
| |
|
> =140
|
19,915
|
2.89 (2.53–3.29)
|
< 0.0001
| |
|
DBP (mmHg)
| | | |
0.9984
|
|
< 90
|
185,636
|
3.29 (3.04–3.56)
|
< 0.0001
| |
|
> =90
|
15,661
|
3.43 (2.90–4.05)
|
< 0.0001
| |
|
Smoker
| | | |
0.6979
|
|
Now
|
11,071
|
3.03 (2.36–3.90)
|
< 0.0001
| |
|
Once
|
2419
|
4.27 (2.30–7.91)
|
< 0.0001
| |
|
Never
|
43,497
|
3.40 (2.84–4.08)
|
< 0.0001
| |
|
Not recorded
|
144,311
|
3.39 (3.13–3.69)
|
< 0.0001
| |
|
Drinker
| | | |
0.2174
|
|
Now
|
1243
|
5.31 (2.34–12.05)
|
< 0.0001
| |
|
Once
|
8496
|
3.65 (2.52–5.28)
|
< 0.0001
| |
|
Never
|
47,248
|
3.33 (2.84–3.90)
|
< 0.0001
| |
|
Not recorded
|
144,311
|
3.39 (3.13–3.69)
|
< 0.0001
| |
|
Family history of diabetes
| | | |
0.1175
|
|
No
|
197,196
|
3.39 (3.15–3.65)
|
< 0.0001
| |
|
Yes
|
4102
|
3.07 (2.10–4.50)
|
< 0.0001
| |
- Note 1: the model was adjusted for sex, age, BMI, LDL-C, TC, Scr, ALT, AST, SBP, DBP, drinking, smoking and family history of diabetes
- Note 2: the model was adjusted for all above variables except the corresponding stratification variable
